Apply to areas of unwanted pigmentation. For stubborn pigmentation, combine with one tiny shake of Skinstitut Vitamin C. For stubborn pigmentation, use in conjunction with Skin InjectTM DNC Derma Roller up to three times per week. **For stubborn pigmentation, use in conjunction withSkin Injectâ„¢ DNC Derma Roller up to three times per week. Avoid eye area.